TNFRSF14
| Recettore del fattore di necrosi tissutale 14 | |
|---|---|
 | |
| Gene | |
| HUGO | TNFRSF14 ATAR; CD270; HVEA; HVEM; LIGHTR; TR2 |
| Entrez | 8764 |
| Locus | Chr. 1 p36.32 |
| Proteina | |
| OMIM | 602746 |
| UniProt | Q92956 |
Il recettore del fattore di necrosi tumorale 14, anche noto come HVEM (dall'acronimo in lingua inglese per herpesvirus entry mediator o mediatore dell'ingresso degli herpesvirus)[1], è una proteina recettoriale che, nell'essere umano, è codificata dal gene TNFRSF14 e fa parte della superfamiglia dei recettori del fattore di necrosi tumorale[2][3][4].
Struttura e funzione
[modifica | modifica wikitesto]Tale recettore è stato identificato come un mediatore dell'ingresso nelle cellule degli Herpes simplex virus, ottenuto tramite il suo legame con la glicoproteina D (gD) dell'envelope virale. La regione citoplasmatica del recettore TNFRSF14 lega numerosi membri della famiglia TRAF, in particolar modo TRAF2[5][6] e TRAF5[5][6], che mediano la trasduzione del segnale che attiva la risposta immunitaria[4]. Nei melanociti la sua espressione è regolata da MITF, il fattore di trascrizione associato a microftalmia[7]. Il recettore interagisce, inoltre, anche con il suo ligando specifico TNFSF14[8][9].
Significato clinico
[modifica | modifica wikitesto]Mutazioni del gene che codifica per tale recettore sono state associate ripetutamente a casi di linfoma diffuso a grandi cellule B[10][11].
Note
[modifica | modifica wikitesto]- ^ Carl Ware, Chapter 25: TNF-Related Cytokines in Immunity, in William Paul (a cura di), Fundamental Immunology, 6th, Philidelphia, PA, Lippincott Williams & Wilkins, 2008, pp. 776–801, ISBN 0-7817-6519-6.
- ^ Montgomery RI, Warner MS, Lum BJ, Spear PG, Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family, in Cell, vol. 87, n. 3, dicembre 1996, pp. 427–36, DOI:10.1016/S0092-8674(00)81363-X, PMID 8898196.
- ^ Kwon BS, Tan KB, Ni J, Oh KO, Lee ZH, Kim KK, Kim YJ, Wang S, Gentz R, Yu GL, Harrop J, Lyn SD, Silverman C, Porter TG, Truneh A, Young PR, A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation, in J Biol Chem, vol. 272, n. 22, giugno 1997, pp. 14272–6, DOI:10.1074/jbc.272.22.14272, PMID 9162061.
- ^ a b Entrez Gene: TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator), su ncbi.nlm.nih.gov.
- ^ a b H Hsu, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle W J, ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5, in J. Biol. Chem., vol. 272, n. 21, UNITED STATES, maggio 1997, pp. 13471–4, DOI:10.1074/jbc.272.21.13471, ISSN 0021-9258, PMID 9153189.
- ^ a b S A Marsters, Ayres T M, Skubatch M, Gray C L, Rothe M, Ashkenazi A, Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1, in J. Biol. Chem., vol. 272, n. 22, UNITED STATES, maggio 1997, pp. 14029–32, DOI:10.1074/jbc.272.22.14029, ISSN 0021-9258, PMID 9162022.
- ^ Hoek KS, Schlegel NC, Eichhoff OM, et al., Novel MITF targets identified using a two-step DNA microarray strategy, in Pigment Cell Melanoma Res., vol. 21, n. 6, 2008, pp. 665–76, DOI:10.1111/j.1755-148X.2008.00505.x, PMID 19067971.
- ^ J Zhang, Salcedo T W, Wan X, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho Y H, Li Y, Moore P A, Wu J, Modulation of T-cell responses to alloantigens by TR6/DcR3, in J. Clin. Invest., vol. 107, n. 11, United States, giugno 2001, pp. 1459–68, DOI:10.1172/JCI12159, ISSN 0021-9738, PMC 209323, PMID 11390428.
- ^ K Y Yu, Kwon B, Ni J, Zhai Y, Ebner R, Kwon B S, A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis, in J. Biol. Chem., vol. 274, n. 20, UNITED STATES, maggio 1999, pp. 13733–6, DOI:10.1074/jbc.274.20.13733, ISSN 0021-9258, PMID 10318773.
- ^ Ryan D. Morin, Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, Tesa M. Severson, Readman Chiu, Matthew Field, Shaun Jackman, Martin Krzywinski, David W. Scott, Diane L. Trinh, Jessica Tamura-Wells, Sa Li, Marlo R. Firme, Sanja Rogic, Malachi Griffith, Susanna Chan, Oleksandr Yakovenko, Irmtraud M. Meyer, Eric Y. Zhao, Duane Smailus, Michelle Moksa, Suganthi Chittaranjan, Lisa Rimsza, Angela Brooks-Wilson, John J. Spinelli, Susana Ben-Neriah, Barbara Meissner, Bruce Woolcock, Merrill Boyle, Helen McDonald, Angela Tam, Yongjun Zhao, Allen Delaney, Thomas Zeng, Kane Tse, Yaron Butterfield, Inanç Birol, Rob Holt, Jacqueline Schein, Douglas E. Horsman, Richard Moore, Steven J. M. Jones, Joseph M. Connors, Martin Hirst, Randy D. Gascoyne e Marco A. Marra, Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma, in Nature, vol. 476, n. 7360, 2011, pp. 298–303, DOI:10.1038/nature10351, ISSN 0028-0836, PMC 3210554, PMID 21796119.
- ^ JG Lohr, Stojanov, P, Lawrence, MS, Auclair, D, Chapuy, B, Sougnez, C, Cruz-Gordillo, P, Knoechel, B, Asmann, YW, Slager, SL, Novak, AJ, Dogan, A, Ansell, SM, Link, BK, Zou, L, Gould, J, Saksena, G, Stransky, N, Rangel-Escareño, C, Fernandez-Lopez, JC, Hidalgo-Miranda, A, Melendez-Zajgla, J, Hernández-Lemus, E, Schwarz-Cruz Y Celis, A, Imaz-Rosshandler, I, Ojesina, AI, Jung, J, Pedamallu, CS, Lander, ES, Habermann, TM, Cerhan, JR, Shipp, MA, Getz, G, Golub, TR, Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing., in Proceedings of the National Academy of Sciences of the United States of America, vol. 109, n. 10, 17 febbraio 2012, pp. 3879–84, DOI:10.1073/pnas.1121343109, PMC 3309757, PMID 22343534.
Bibliografia
[modifica | modifica wikitesto]- Hsu H, Solovyev I, Colombero A, et al., ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5, in J. Biol. Chem., vol. 272, n. 21, 1997, pp. 13471–4, DOI:10.1074/jbc.272.21.13471, PMID 9153189.
- Marsters SA, Ayres TM, Skubatch M, et al., Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1, in J. Biol. Chem., vol. 272, n. 22, 1997, pp. 14029–32, DOI:10.1074/jbc.272.22.14029, PMID 9162022.
- Mauri DN, Ebner R, Montgomery RI, et al., LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator, in Immunity, vol. 8, n. 1, 1998, pp. 21–30, DOI:10.1016/S1074-7613(00)80455-0, PMID 9462508.
- Lee CH, Chinpaisal C, Wei LN, Cloning and Characterization of Mouse RIP140, a Corepressor for Nuclear Orphan Receptor TR2, in Mol. Cell. Biol., vol. 18, n. 11, 1998, pp. 6745–55, PMC 109258, PMID 9774688.
- Kelly K, Manos E, Jensen G, et al., APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death, in Cancer Res., vol. 60, n. 4, 2000, pp. 1021–7, PMID 10706119.
- Zhang J, Salcedo TW, Wan X, et al., Modulation of T-cell responses to alloantigens by TR6/DcR3, in J. Clin. Invest., vol. 107, n. 11, 2001, pp. 1459–68, DOI:10.1172/JCI12159, PMC 209323, PMID 11390428.
- Franco PJ, Farooqui M, Seto E, Wei LN, The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases, in Mol. Endocrinol., vol. 15, n. 8, 2001, pp. 1318–28, DOI:10.1210/me.15.8.1318, PMID 11463856.
- Carfí A, Willis SH, Whitbeck JC, et al., Herpes simplex virus glycoprotein D bound to the human receptor HveA, in Mol. Cell, vol. 8, n. 1, 2001, pp. 169–79, DOI:10.1016/S1097-2765(01)00298-2, PMID 11511370.
- Bobik A, Kalinina N, Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis, in Arterioscler. Thromb. Vasc. Biol., vol. 21, n. 12, 2002, pp. 1873–5, PMID 11742858.
- Struyf F, Posavad CM, Keyaerts E, et al., Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals, in J. Infect. Dis., vol. 185, n. 1, 2002, pp. 36–44, DOI:10.1086/338116, PMID 11756979.
- Carfí A, Gong H, Lou H, et al., Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA, in Acta Crystallogr. D Biol. Crystallogr., vol. 58, Pt 5, 2002, pp. 836–8, DOI:10.1107/S0907444902001270, PMID 11976496.
- Hu YC, Shyr CR, Che W, et al., Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor, in J. Biol. Chem., vol. 277, n. 37, 2002, pp. 33571–9, DOI:10.1074/jbc.M203531200, PMID 12093804.
- Gill RM, Ni J, Hunt JS, Differential Expression of LIGHT and Its Receptors in Human Placental Villi and Amniochorion Membranes, in Am. J. Pathol., vol. 161, n. 6, 2003, pp. 2011–7, DOI:10.1016/S0002-9440(10)64479-3, PMC 1850908, PMID 12466117.
- Strausberg RL, Feingold EA, Grouse LH, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences, in Proc. Natl. Acad. Sci. U.S.A., vol. 99, n. 26, 2003, pp. 16899–903, DOI:10.1073/pnas.242603899, PMC 139241, PMID 12477932.
- Bender FC, Whitbeck JC, Ponce de Leon M, et al., Specific Association of Glycoprotein B with Lipid Rafts during Herpes Simplex Virus Entry, in J. Virol., vol. 77, n. 17, 2003, pp. 9542–52, DOI:10.1128/JVI.77.17.9542-9552.2003, PMC 187402, PMID 12915568.
- Clark HF, Gurney AL, Abaya E, et al., The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment, in Genome Res., vol. 13, n. 10, 2003, pp. 2265–70, DOI:10.1101/gr.1293003, PMC 403697, PMID 12975309.
- Jung HW, La SJ, Kim JY, et al., High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases, in Exp. Mol. Med., vol. 35, n. 6, 2004, pp. 501–8, PMID 14749527.
- Krummenacher C, Baribaud F, Ponce de Leon M, et al., Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus, in Virology, vol. 322, n. 2, 2004, pp. 286–99, DOI:10.1016/j.virol.2004.02.005, PMID 15110526.
