Utente:Chchowmein/sandbox/2
- Anticorpi monoclonali
- Tocilizumab, farmaco anti-artrite utilizzato anche nei casi di lupus e psoriasi; in 24 ore di terapia ha evidenziato ottimi risultati su pazienti in ventilazione assistita.[1]
- NB: Al 14/3/2020 non risulta nessuna pubblicazione censista da Pubmed sull'uso del Tocilizumab contro COVID-19.[2]
Tocilizumab, an en:immunosuppressive drug, mainly used for the treatment of en:rheumatoid arthritis, has been included in treatment guidelines by China's w:en:National Health Commission after a completed preliminary study by the en:University of Science and Technology of China.[3][4] The drug is undergoing testing in five hospitals in Italy after showing positive results in people with severe disease.[5][6] Combined with a serum ferritin blood test to identify cytokine storms, it is meant to counter such developments which are thought to be the cause of death in some patients.[7][8] The w:en:interleukin-6 w:en:receptor antagonist was approved by the FDA for treatment against cytokine release syndrome induced by a different cause, CAR T cell therapy, in 2017.[9]
- ^ Coronavirus, l’oncologo: “Subito protocollo nazionale per usare Tocilizumab. È efficace contro la polmonite da Covid 19”, su ilfattoquotidiano.it, 11 marzo 2020.
- ^ No items found - Tocilizumab AND Covid-19 - PubMed - NCBI, su ncbi.nlm.nih.gov. URL consultato il 15 marzo 2020.
- ^ China approves use of Roche drug in battle against coronavirus complications, su reuters.com, Reuters, 3 March 2020.
- ^ Effective Treatment of Severe COVID-19 Patients with Tocilizumab, su chinaxiv.org, 5 March 2020.
- ^ 3 patients get better on arthritis drug, su ansa.it, 5 March 2020.
- ^ Coronavirus, via libera dell'Aifa al farmaco anti-artrite efficace su 3 pazienti e a un antivirale: test in 5 centri, su ilmessaggero.it, Il Messaggero.
- ^ How doctors can potentially significantly reduce the number of deaths from Covid-19, su vox.com, Vox.
- ^ Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China, in Intensive Care Medicine, 3 March 2020, DOI:10.1007/s00134-020-05991-x.
- ^ China turns Roche arthritis drug Actemra against COVID-19 in new treatment guidelines, su fiercepharma.com, FiercePharma.