Voce principale: Screen Actors Guild Awards.

La dodicesima cerimonia del Premio SAG si è svolta il 29 gennaio 2006 allo Shrine Exposition Center di Los Angeles.

• Philip Seymour Hoffman – Truman Capote - A sangue freddo (Capote)
• Russell Crowe – Cinderella Man - Una ragione per lottare (Cinderella Man)
• Heath Ledger – I segreti di Brokeback Mountain (Brokeback Mountain)
• Joaquin Phoenix – Quando l'amore brucia l'anima (Walk the Line)
• David Strathairn – Good Night, and Good Luck.

• Reese Witherspoon – Quando l'amore brucia l'anima
• Judi Dench – Lady Henderson presenta (Mrs. Henderson Presents)
• Felicity Huffman – Transamerica
• Charlize Theron – North Country - Storia di Josey (North Country)
• Zhang Ziyi – Memorie di una Geisha (Memoirs of a Geisha)

• Paul Giamatti – Cinderella Man - Una ragione per lottare
• Don Cheadle – Crash - Contatto fisico (Crash)
• George Clooney – Syriana
• Matt Dillon – Crash - Contatto fisico
• Jake Gyllenhaal – I segreti di Brokeback Mountain

• Rachel Weisz – The Constant Gardener - La cospirazione (The Constant Gardner)
• Amy Adams – Junebug
• Catherine Keener – Truman Capote - A sangue freddo
• Frances McDormand – North Country - Storia di Josey
• Michelle Williams – I segreti di Brokeback Mountain

• Crash - Contatto fisico
  Chris "Ludacris" Bridges, Sandra Bullock, Don Cheadle, Matt Dillon, Jennifer Esposito, William Fichtner, Brendan Fraser, Terrence Howard, Thandie Newton, Ryan Phillippe, Larenz Tate
• Good Night, and Good Luck.
  Rose Abdoo, Alex Borstein, Robert John Burke, Patricia Clarkson, George Clooney, Jeff Daniels, Reed Diamond, Tate Donovan, Robert Downey Jr., Grant Heslov, Peter Jacobson, Frank Langella, Tom McCarthy, Dianne Reeves, Matt Ross, David Strathairn, Ray Wise
• Hustle & Flow - Il colore della musica (Hustle & Flow)
  Anthony Anderson, Chris "Ludacris" Bridges, Isaac Hayes, Taraji P. Henson, Terrence Howard, Taryn Manning, Elise Neal, Paula Jai Parker, D.J. Qualls
• I segreti di Brokeback Mountain
  Linda Cardellini, Anna Faris, Jake Gyllenhaal, Anne Hathaway, Heath Ledger, Randy Quaid, Michelle Williams
• Truman Capote - A sangue freddo
  Bob Balaban, Marshall Bell, Clifton Collins Jr., Chris Cooper, Bruce Greenwood, Philip Seymour Hoffman, Catherine Keener, Mark Pellegrino

• Paul Newman – Le cascate del cuore (Empire Falls)
• Kenneth Branagh – Franklin D. Roosevelt - Un uomo, un presidente (Warm Springs)
• Ted Danson – Scacco matto nel Bronx (Knights of the South Bronx)
• Ed Harris – Le cascate del cuore
• Christopher Plummer – Our Fathers

• S. Epatha Merkerson – Lackawanna Blues
• Tonantzin Carmelo – Into The West
• Cynthia Nixon – Franklin D. Roosevelt - Un uomo, un presidente
• Joanne Woodward – Le cascate del cuore
• Robin Wright Penn – Le cascate del cuore

• Kiefer Sutherland – 24
• Alan Alda – West Wing - Tutti gli uomini del Presidente (The West Wing)
• Patrick Dempsey – Grey's Anatomy
• Hugh Laurie – Dr. House - Medical Division (House M.D.)
• Ian McShane – Deadwood

• Sandra Oh – Grey's Anatomy
• Patricia Arquette – Medium
• Geena Davis – Una donna alla Casa Bianca (Commander in Chief)
• Mariska Hargitay – Law & Order - Unità vittime speciali (Law & Order: Special Victims Unit)
• Kyra Sedgwick – The Closer

• Sean Hayes – Will & Grace
• Larry David – Curb Your Enthusiasm
• Jason Lee – My Name Is Earl
• William Shatner – Boston Legal
• James Spader – Boston Legal

• Felicity Huffman – Desperate Housewives
• Candice Bergen – Boston Legal
• Patricia Heaton – Tutti amano Raymond
• Megan Mullally – Will & Grace
• Mary-Louise Parker – Weeds

• Lost
  Adewale Akinnuoye-Agbaje, Naveen Andrews, Emilie de Ravin, Matthew Fox, Jorge Garcia, Maggie Grace, Josh Holloway, Malcolm David Kelley, Daniel Dae Kim, Yunjin Kim, Evangeline Lilly, Dominic Monaghan, Terry O'Quinn, Harold Perrineau, Michelle Rodriguez, Ian Somerhalder, Cynthia Watros
• Grey's Anatomy
  Justin Chambers, Patrick Dempsey, Katherine Heigl, T.R. Knight, Sandra Oh, James Pickens Jr., Ellen Pompeo, Kate Walsh, Isaiah Washington, Chandra Wilson
• Six Feet Under
  Lauren Ambrose, Joanna Cassidy, Frances Conroy, James Cromwell, Rachel Griffiths, Michael C. Hall, Tina Holmes, Peter Krause, Justina Machado, Freddy Rodríguez, Jeremy Sisto, Mathew St. Patrick
• The Closer
  G. W. Bailey, Michael Paul Chan, Raymond Cruz, Gina Ravera, Tony Denison, Robert Gossett, Corey Reynolds, Kyra Sedgwick, J.K. Simmons, Jon Tenney
• West Wing - Tutti gli uomini del Presidente
  Alan Alda, Kristin Chenoweth, Janeane Garofalo, Dulé Hill, Allison Janney, Joshua Malina, Mary McCormack, Janel Moloney, Teri Polo, Richard Schiff, Martin Sheen, Jimmy Smits, John Spencer, Bradley Whitford

• Desperate Housewives
  Andrea Bowen, Mehcad Brooks, Ricardo Antonio Chavira, Marcia Cross, Steven Culp, James Denton, Teri Hatcher, Felicity Huffman, Brent Kinsman, Shane Kinsman, Eva Longoria, Mark Moses, Doug Savant, Nicollette Sheridan, Brenda Strong, Alfre Woodard
• Arrested Development
  Will Arnett, Jason Bateman, Michael Cera, David Cross, Portia De Rossi, Tony Hale, Alia Shawkat, Jeffrey Tambor, Jessica Walter
• Boston Legal
  René Auberjonois, Ryan Michelle Bathe, Candice Bergen, Julie Bowen, Justin Mentell, Rhona Mitra, Monica Potter, William Shatner, James Spader, Mark Valley
• Curb Your Enthusiasm
  Shelley Berman, Larry David, Susie Essman, Jeff Garlin, Cheryl Hines, Richard Lewis
• Tutti amano Raymond
  Peter Boyle, Brad Garrett, Patricia Heaton, Doris Roberts, Ray Romano, Madylin Sweeten
• My Name Is Earl
  Jason Lee, Jaime Pressly, Eddie Steeples, Ethan Suplee, Nadine Velazquez

• Shirley Temple

• Sito ufficiale (12th Screen Actors Guild Awards), su sagawards.org.

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