TNFRSF17
| Recettore del fattore di necrosi tissutale 17 | |
|---|---|
 | |
| Gene | |
| HUGO | TNFRSF17 BCM; BCMA; CD269 |
| Entrez | 608 |
| Locus | Chr. 16 p13.13 |
| Proteina | |
| OMIM | 109545 |
| UniProt | Q02223 |
Il recettore del fattore di necrosi tumorale 17 è una proteina recettoriale che, nell'essere umano, è codificata dal gene TNFRSF17 e fa parte della superfamiglia dei recettori del fattore di necrosi tumorale[1][2][3].
Espressione e ruolo
[modifica | modifica wikitesto]Il recettore si trova espresso preferenzialmente nei linfociti B maturi ed è importante nello sviluppo di tali cellule e nei meccanismi di autoimmunità[3].
Interazioni
[modifica | modifica wikitesto]Tale recettore interagisce specificatamente con il fattore TNFSF13B attivante i linfociti B[4][5] al quale si lega tramite un dominio N-terminale conservato, BCMA TALL-1[6] e porta all'attivazione dei meccanismi di trasduzione mediati da NF-kappaB e MAPK8/JNK. Lega inoltre vari membri della famiglia TRAF coinvolti nella proliferazione e nella sopravvivenza cellulare[3].
Note
[modifica | modifica wikitesto]- ^ Laabi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ, Tsapis A, A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma, in EMBO J, vol. 11, n. 11, novembre 1992, pp. 3897–904, PMC 556899, PMID 1396583.
- ^ Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A, The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed, in Nucleic Acids Res, vol. 22, n. 7, maggio 1994, pp. 1147–54, DOI:10.1093/nar/22.7.1147, PMC 523635, PMID 8165126.
- ^ a b c Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17, su ncbi.nlm.nih.gov.
- ^ Yingfang Liu, Hong Xia, Kappler John, Jiang Ling, Zhang Rongguang, Xu Liangguo, Pan Cheol-Ho, Martin Wesley E, Murphy Robert C, Shu Hong-Bing, Dai Shaodong, Zhang Gongyi, Ligand-receptor binding revealed by the TNF family member TALL-1, in Nature, vol. 423, n. 6935, England, maggio. 2003, pp. 49–56, DOI:10.1038/nature01543, ISSN 0028-0836, PMID 12721620.
- ^ H B Shu, Johnson H, B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1, in Proc. Natl. Acad. Sci. U.S.A., vol. 97, n. 16, UNITED STATES, agosto 2000, pp. 9156–61, DOI:10.1073/pnas.160213497, ISSN 0027-8424, PMC 16838, PMID 10908663.
- ^ Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, Zhang G, Ligand-receptor binding revealed by the TNF family member TALL-1, in Nature, vol. 423, n. 6935, maggio 2003, pp. 49–56, DOI:10.1038/nature01543, PMID 12721620.
Bibliografia
[modifica | modifica wikitesto]- Treml LS, Crowley JE, Cancro MP, BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells, in Semin. Immunol., vol. 18, n. 5, 2007, pp. 297–304, DOI:10.1016/j.smim.2006.07.001, PMID 16919470.
- Mackay F, Leung H, The role of the BAFF/APRIL system on T cell function, in Semin. Immunol., vol. 18, n. 5, 2007, pp. 284–9, DOI:10.1016/j.smim.2006.04.005, PMID 16931039.
- Gras MP, Laâbi Y, Linares-Cruz G, et al., BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes, in Int. Immunol., vol. 7, n. 7, 1996, pp. 1093–106, DOI:10.1093/intimm/7.7.1093, PMID 8527407.
- Loftus BJ, Kim UJ, Sneddon VP, et al., Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q, in Genomics, vol. 60, n. 3, 1999, pp. 295–308, DOI:10.1006/geno.1999.5927, PMID 10493829.
- Gross JA, Johnston J, Mudri S, et al., TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease, in Nature, vol. 404, n. 6781, 2000, pp. 995–9, DOI:10.1038/35010115, PMID 10801128.
- Hatzoglou A, Roussel J, Bourgeade MF, et al., TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase, in J. Immunol., vol. 165, n. 3, 2000, pp. 1322–30, PMID 10903733.
- Shu HB, Johnson H, B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1, in Proc. Natl. Acad. Sci. U.S.A., vol. 97, n. 16, 2000, pp. 9156–61, DOI:10.1073/pnas.160213497, PMC 16838, PMID 10908663.
- Yu G, Boone T, Delaney J, et al., APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity, in Nat. Immunol., vol. 1, n. 3, 2001, pp. 252–6, DOI:10.1038/79802, PMID 10973284.
- Kawasaki A, Tsuchiya N, Fukazawa T, et al., Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis, in Genes Immun., vol. 2, n. 5, 2001, pp. 276–9, DOI:10.1038/sj.gene.6363770, PMID 11528522.
- Strausberg RL, Feingold EA, Grouse LH, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences, in Proc. Natl. Acad. Sci. U.S.A., vol. 99, n. 26, 2003, pp. 16899–903, DOI:10.1073/pnas.242603899, PMC 139241, PMID 12477932.
- Novak AJ, Darce JR, Arendt BK, et al., Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival, in Blood, vol. 103, n. 2, 2004, pp. 689–94, DOI:10.1182/blood-2003-06-2043, PMID 14512299.
- Hymowitz SG, Patel DR, Wallweber HJ, et al., Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding, in J. Biol. Chem., vol. 280, n. 8, 2005, pp. 7218–27, DOI:10.1074/jbc.M411714200, PMID 15542592.
- Bellucci R, Alyea EP, Chiaretti S, et al., Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane receptor, in Blood, vol. 105, n. 10, 2005, pp. 3945–50, DOI:10.1182/blood-2004-11-4463, PMC 1895080, PMID 15692072.
- Hendriks J, Planelles L, de Jong-Odding J, et al., Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation, in Cell Death Differ., vol. 12, n. 6, 2005, pp. 637–48, DOI:10.1038/sj.cdd.4401647, PMID 15846369.
- Chiu A, Xu W, He B, et al., Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL, in Blood, vol. 109, n. 2, 2007, pp. 729–39, DOI:10.1182/blood-2006-04-015958, PMC 1785096, PMID 16960154.
- Smirnova AS, Andrade-Oliveira V, Gerbase-Delima M, Identification of new splice variants of the genes BAFF and BCMA, in Molecular Immunology, vol. 45, n. 4, 2008, pp. 1179–1183, DOI:10.1016/j.molimm.2007.07.028, PMID 17825416.
